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Cardarine (GW-501516, GW1516, GSK-516 or endurobol) is a substance that acts as a modulator of hormone receptors. GW-501516 AMP activates protein kinase, the activation stimulates glucose uptake in skeletal muscles. The formulation has been proposed as a potential treatment of obesity and related with it conditions, particularly when used in combination with a synergistic compound AICAR.
Cardarine is a selective PPARδ receptor activator. It displays a high affinity (K i = 1 Nm) and capacity (EC 50 = 1 Nm) of the PPARδ with a > 1000 times selectivity over PPARa and PPARy.
In mammals, the aplication of GW-501516, involves the activator PGC-1a by acting on PPARδ. The PPARδ coactivator increases the expression of proteins involved in energy costs. In addition, in rats treated with cardarine recognised an increased metabolism of fatty acid in skeletal muscles and protection against diet leading to obesity and type II diabetes! In obese rhesus monkeys, GW-501516 increased the level of high density lipoprotein (HDL) and lowered the level of lipoproteins of very low density (VLDL). Mechanisms of action of PPARδ agonists slightly increase HDL. It seems to be due to increased expression of ABCA1 – the transporter of cholesterol.
When administered cardarine, it was shown that it reverses metabolic disorders in obese people with a pre-diabetes metabolic syndrome, probably by stimulating the oxidation of fatty acids. Cardarine was proposed as a potential preparation for the treatment of obesity and related with it conditions. With AICAR you can greatly improve the efficiency of GW-501516.
There are two main uses GW-501516 in sport.
Cardarine is not a hormone, so it does not block the HPTA. Despite its oral form, it does not contain a harmful methyl group.
A recommended dose for cardarine is 10-20 mg, and the cyclicality of application is 8 weeks. Thanks to the half-life of approximately 20-24 hours, you can use the preparation once a day. In the case of larger doses you can take two portions every 8-10 hours.